Support longevity at the mitochondrial level

randomized, placebo-controlled, double-blind

Mitopure® Renews Mitochondria

Taking 500 mg of Mitopure® daily for four months increased mitophagy by 39% compared to control.

Methods

Randomized, double-blind, placebo-controlled trial where 88 sedentary healthy participants took 500 mg or 1000 mg of Mitopure or placebo daily for four months, without changing their diet or physical activity.

Strength, physical performance, mitophagy and mitochondrial metabolism in skeletal muscle were measured.

• Number of participants: 88
• Age of participants: 40-65
• Duration of study: 16 weeks

Results

Participants taking 500 mg of Mitopure® daily for four months increased mitophagy by 39% compared to control. Mitophagy is the body's quality-control system for recycling damaged mitochondria. By activating mitophagy, Mitopure helps renew mitochondria®.

randomized, placebo-controlled, double-blind

Mitopure® Increases Muscle Strength

Participants taking 500 mg of Mitopure® daily increased muscle strength by up to 12% after four months.

Methods

Randomized, double-blind, placebo-controlled trial where 88 sedentary healthy participants took 500 mg or 1000 mg of Mitopure® or placebo daily for four months, without changing their diet or physical activity.

Strength, physical performance, mitophagy and mitochondrial metabolism in skeletal muscle were measured.

• Number of participants: 88
• Age of participants: 40-65
• Duration of study: 16 weeks

Results

Participants taking 500 mg of Mitopure daily for four months increased muscle strength by up to 12% without changing their diet or exercise. The control group lost nearly 10% of muscle strength in the same time frame, highlighting the effects of inaction.

randomized, placebo-controlled, double-blind

Mitopure® Supports Cellular Energy Production

Mitopure® improves gene expression linked to mitochondrial function and mitophagy after four weeks, which supports cellular energy production.

Methods

Randomized, double-blind, placebo-controlled trial of healthy, sedentary, older adults. Participants received daily doses of Mitopure at either 250 mg, 500 mg, 1000 mg or a placebo. Changes in mitochondrial health biomarkers were measured.

• Number of participants: 60
• Age of participants: 61-85
• Duration of study: 4 weeks

Results

Taking 500 mg of Mitopure® daily for four weeks improves key markers of mitochondrial health, activates mitophagy and supports energy metabolism. The gene expression patterns observed in human skeletal muscle after taking Mitopure® mirror that of exercise.

randomized, placebo-controlled, double-blind

Mitopure® Is More Bioavailable Than Food

Mitopure® is designed to bypass the gut microbiome conversion and increase plasma Urolithin A levels faster and more consistently than drinking pomegranate juice.

Methods

Randomized, two-period crossover study where participants had 500 mg of Mitopure® or 8 ounces of pomegranate juice during the first study period, followed by a washout period, and then switched. Blood samples were collected to assess Urolithin A levels.

• Number of participants: 100
• Age of participants: 20-80

Results

Only 2% of the population were high producers of Urolithin A at baseline. After drinking pomegranate juice, this jumped to 40%, and after supplementing with Mitopure®, 100% of participants achieved high producer levels.

Mitopure® increased Urolithin A levels six-fold compared to pomegranate juice intake. Mitopure is also absorbed faster and more consistently, achieving peak levels after six hours compared to pomegranate’s 24 hours.